ABCG1 regulates pulmonary surfactant metabolism in mice and men
نویسندگان
چکیده
منابع مشابه
ABCG1 regulates pulmonary surfactant metabolism in mice and men.
Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are restricted to epithelial type 2 (T2) pneumocytes (also called T2 cells). Clearance of surfactant is dependent upon T2 cells and macrophages. ABCG1 is highly expressed in both T2 cells and macrophages. ABCG1-deficient mice accumulate surfactan...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2017
ISSN: 0022-2275
DOI: 10.1194/jlr.m075101